Cyclin D2 antibody

Catalog No. ABIN6298006

This Rabbit Polyclonal antibody specifically detects Cyclin D2 in . It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Cyclin D2 antibody (ABIN6298006)

Target: Cyclin D2 (CCND2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin D2 antibody is un-conjugated

Application: Please inquire

Product Details anti-Cyclin D2 Antibody

Purpose: Rabbit Anti-Cyclin D2 (Ab-280) Antibody,

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for Cyclin D2

Target: Cyclin D2 (CCND2)

Alternative Name: Cyclin D2

Background:

Target Description: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Gene Symbol: CCND2

Gene ID: 894

UniProt: P30279

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases